ncRNA name | hsa-miR-200b |
ncRNA Category | miRNA |
Disease name | diabetic retinopathy (DR) |
Species | Homo sapiens |
Tissues/Cell_line | human retinal microvascular endothelial cells |
Methods | qPCR, Western blot, ELISA, immunofluorescence |
Expression pattern | down-regulated |
Functional description | Glucose caused decreased expression of mRNA and protein levels of endothelial markers and increased expression of mesenchymal markers with reduced miR-200b. A glucose-like effect was seen using TGFβ1 peptide. Such changes were mediated by miR-200b and p300. |
PubMed ID | 25335984 |
Year | 2014 |
Title | Mechanisms of endothelial to mesenchymal transition in the retina in diabetes. |
Drug-related ncRNA | NO |
Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.